Advanced melanoma is extremely difficult to treat. Chemotherapies and radiation treatments that commonly cure other cancers have no effect on melanoma. To get a perspective, go to http://www.centerwatch.com/clinical-trials/listings/studylist.aspx?CatID=196&mp=shade and see the scores of clinical trials currently active. And this doesn't count the trials that have already been completed (failed) or are not accepting new patients. There are also tons of 'alternative medicine' ideas; various combinations of roots and berries that sound good, but have never been proved to do anything at all.
Right now there are two FDA approved treatments for melanoma: interferon and high-dose interleukin 2. Interferon is a year long treatment that makes you feel sick as a dog, might slow the progression for a few months in about 20% of cases but has never resulted in remission or increased life expectancy. I decided to pass, placing the ability to fully enjoy my life as the higher priority. In other words, I'd rather be fishing with friends than be in a hospital bed, especially when the hospital stay will not allow me to live longer.
The other option is high-dose interleukin-2. This is what I am currently considering. It only has positive effects in about 20% of cases, usually in the form of slowed growth or some shrinkage of tumors. BUT - in about 5% of cases there is full remission. Why haven't I done this yet? Because it still doesn't work 95% of the time and is very toxic. The short story is you go into intensive care and they start administering the IL2 every 4 hours up to a max of 12 times. they monitor you carefully and when your body can't tolerate it any more they stop, usually at about 9-11 times. That takes two days and they keep you in the hospital for another 3 until you can go home to recover for another 9 days, then repeat. It's a month in hell, with small chance of positive result, but it is not the only reasonable option so assuming my heart can take it I'll do it.
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